Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867788 | 1.00 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BAPP | |
| SCHEMBL6867273 | 0.93 | ALDH1A1 (0.43) | MCHR1ADRA2AHRH1HTR2BRAB9A | |
| SCHEMBL6867278 | 0.93 | ALDH1A1 (0.43) | MCHR1ADRA2AHRH1HTR2BRAB9A | |
| SCHEMBL6875065 | 0.91 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BALDH1A1 | |
| SCHEMBL6875058 | 0.91 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BALDH1A1 | |
| SCHEMBL6876990 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BRAB9A | |
| SCHEMBL6876996 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BRAB9A | |
| SCHEMBL6879289 | 0.89 | ALDH1A1 (0.45) | MCHR1ADRA2ARAB9AALDH1A1MAPK1 | |
| SCHEMBL6879286 | 0.89 | ALDH1A1 (0.45) | MCHR1ADRA2ARAB9AALDH1A1MAPK1 | |
| SCHEMBL6875135 | 0.88 | MCHR1 (0.41) | MCHR1ADRA2AHRH1HTR2BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |