Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 3/20 | 0.45 |
| ▸ | WNT3A | P56704 | 3/20 | 0.45 |
| ▸ | CASR | P41180 | 6/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15369318 | 0.85 | CASR (0.49) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL6868445 | 0.84 | CASR (0.62) | CTNNB1WNT3ACASRADRA2CSLC6A2 | |
| Hydrochloric Acid SCHEMBL1493965 | 0.83 | CASR (0.62) | CTNNB1WNT3ACASRADRA2CSLC6A2 | |
| Hydrochloric Acid SCHEMBL1493964 | 0.83 | CASR (0.62) | CTNNB1WNT3ACASRADRA2CSLC6A2 | |
| SCHEMBL14063803 | 0.77 | CYP1A2 (0.50) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL12391540 | 0.76 | CTNNB1 (0.40) | CTNNB1WNT3AOPRM1OPRK1EPHX2 | |
| SCHEMBL5473700 | 0.76 | CASR (0.57) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL5473697 | 0.76 | CASR (0.57) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL6867694 | 0.75 | CASR (0.45) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL6868490 | 0.74 | CASR (0.71) | CASRADRA2CSLC6A2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475641-B1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM SPA (IT) | 2013-11-06 | — | — | EP | disclosed |
| EP-2358659-B1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM SPA (IT) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011029833-A1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2011-03-17 | — | — | WO | disclosed |