Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.62 |
| ▸ | HTR2C | P28335 | 3/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.62 |
| ▸ | DRD3 | P35462 | 3/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.62 |
| ▸ | HRH1 | P35367 | 2/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | GHSR | Q92847 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MLNR | O43193 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1493964 | 0.99 | CASR (0.62) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL1493965 | 0.99 | CASR (0.62) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL6867893 | 0.84 | CTNNB1 (0.45) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL15369318 | 0.83 | CASR (0.49) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL6813377 | 0.81 | NPSR1 (0.64) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL6813375 | 0.81 | NPSR1 (0.64) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL17915496 | 0.78 | CASR (0.87) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL17053439 | 0.78 | CASR (0.87) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL14313029 | 0.78 | ADRA2C (0.46) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL7941382 | 0.78 | ADRA2C (0.46) | CASRADRA2CSLC6A2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522869-B2 | Process for preparing Cinacalcet hydrochloride | ZACH SYSTEM S.P.A. (IT) | 2016-12-20 | — | — | US | disclosed |
| US-20140296574-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2014-10-02 | — | — | US | disclosed |
| US-8637708-B2 | Process for preparing cinacalcet | ZACH SYSTEM S.P.A. (IT) | 2014-01-28 | — | — | US | disclosed |
| EP-2358659-B1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM SPA (IT) | 2012-12-26 | — | — | EP | disclosed |
| US-20120238778-A1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2012-09-20 | — | — | US | disclosed |
| US-20110306794-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | ZACH SYSTEM S.P.A. (IT) | 2011-12-15 | — | — | US | disclosed |
| US-20110207965-A1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2011-08-25 | — | — | US | disclosed |
| WO-2011029833-A1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2011-03-17 | — | — | WO | disclosed |
| WO-2010094674-A2 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | ZACH SYSTEM S.P.A. (IT) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010049293-A2 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238778-A1 | PROCESS FOR PREPARING CINACALCET | CA9, PCSK9, REN | CASR 975/4885ADRA2C 1775/4885SLC6A2 1346/4885 |
| US-20140296574-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | SLC5A1, CA9, REN | CASR 207/4885ADRA2C 657/4885SLC6A2 323/4885 |
| US-20110207965-A1 | PROCESS FOR PREPARING CINACALCET | VIP, KRAS, C9 | CASR 1351/4885ADRA2C 753/4885SLC6A2 1356/4885 |
| US-20110306794-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | SLC5A1, CA9, REN | CASR 207/4885ADRA2C 657/4885SLC6A2 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.