Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868372 | 1.00 | TDP1 (0.43) | TDP1L3MBTL1LMNANPSR1THRB | |
| SCHEMBL6873160 | 0.89 | LMNA (0.55) | TDP1L3MBTL1LMNANPSR1THRB | |
| SCHEMBL6873156 | 0.89 | LMNA (0.55) | TDP1L3MBTL1LMNANPSR1THRB | |
| SCHEMBL6457924 | 0.88 | L3MBTL1 (0.46) | TDP1L3MBTL1LMNANPSR1THRB | |
| SCHEMBL6878924 | 0.88 | L3MBTL1 (0.46) | TDP1L3MBTL1LMNANPSR1THRB | |
| SCHEMBL6457916 | 0.88 | L3MBTL1 (0.46) | TDP1L3MBTL1LMNANPSR1THRB | |
| SCHEMBL6878919 | 0.88 | L3MBTL1 (0.46) | TDP1L3MBTL1LMNANPSR1THRB | |
| SCHEMBL6876902 | 0.88 | TDP1 (0.59) | TDP1L3MBTL1LMNANPSR1ALDH1A1 | |
| SCHEMBL6876908 | 0.88 | TDP1 (0.59) | TDP1L3MBTL1LMNANPSR1ALDH1A1 | |
| SCHEMBL5520915 | 0.86 | MCHR1 (0.56) | TDP1L3MBTL1LMNATHRBALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |