Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663908 | 0.80 | HCAR2 (0.52) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL663907 | 0.80 | HCAR2 (0.52) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| Hydrochloric Acid SCHEMBL665363 | 0.78 | MAPT (0.50) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| Hydrochloric Acid SCHEMBL665362 | 0.78 | MAPT (0.50) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| Water SCHEMBL28234797 | 0.77 | MAPT (0.49) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL21005410 | 0.77 | MAPT (0.49) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL9205853 | 0.77 | MAPT (0.53) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL9205850 | 0.77 | MAPT (0.53) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL9473792 | 0.75 | MAPT (0.51) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL9473797 | 0.75 | MAPT (0.51) | MAPTHCAR2ALDH1A1TTRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376492-B1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-04-08 | — | — | EP | disclosed |
| US-8981092-B2 | Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-17 | — | — | US | disclosed |
| US-8981092-B2 | Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-17 | — | — | US | disclosed |
| EP-2528918-B1 | 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2014-09-10 | — | — | EP | disclosed |
| US-8772279-B2 | 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one derivatives as protein kinase modulators | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2014-07-08 | — | — | US | disclosed |
| US-8772279-B2 | 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one derivatives as protein kinase modulators | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2014-07-08 | — | — | US | disclosed |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-05-30 | — | — | US | disclosed |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-05-30 | — | — | US | disclosed |
| US-8394802-B2 | 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one derivatives for the modulation of the activity of protein kinases | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-03-12 | — | — | US | disclosed |
| US-8394802-B2 | 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one derivatives for the modulation of the activity of protein kinases | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-03-12 | — | — | US | disclosed |
| US-20130029974-A1 | 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-01-31 | — | — | US | disclosed |
| US-20130029974-A1 | 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-01-31 | — | — | US | disclosed |
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2011-10-13 | — | — | US | disclosed |
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2011-10-13 | — | — | US | disclosed |
| WO-2011092120-A1 | 6,7- DIHYDROIMIDAZO [1,5-A] PYRAZIN-8 (5H) - ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | disclosed |
| WO-2010031816-A1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | PDK1, PDPK1, CDK3 | MAPT 604/4885HCAR2 4155/4885ALDH1A1 1974/4885 |
| US-20130029974-A1 | 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | MAP3K6, MAP3K1, MAP3K5 | MAPT 906/4885HCAR2 4105/4885ALDH1A1 3554/4885 |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | MAP3K15, MAP3K1, MAP3K3 | MAPT 991/4885HCAR2 4029/4885ALDH1A1 2930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.