Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663907 | 1.00 | HCAR2 (0.52) | HCAR2MAPTALDH1A1TTRDPP4 | |
| Hydrochloric Acid SCHEMBL665362 | 0.98 | MAPT (0.50) | HCAR2MAPTALDH1A1TTRDPP4 | |
| Hydrochloric Acid SCHEMBL665363 | 0.98 | MAPT (0.50) | HCAR2MAPTALDH1A1TTRDPP4 | |
| Water SCHEMBL28234797 | 0.96 | MAPT (0.49) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL21005410 | 0.84 | MAPT (0.49) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL27791479 | 0.84 | HCAR2 (0.55) | HCAR2MAPTALDH1A1NPSR1ATM | |
| SCHEMBL16888855 | 0.81 | ATM (0.66) | HCAR2MAPTALDH1A1NPSR1ATM | |
| SCHEMBL6868446 | 0.80 | MAPT (0.53) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL17315765 | 0.79 | MAPT (0.47) | HCAR2MAPTALDH1A1CYP3A4ATM | |
| SCHEMBL17315766 | 0.79 | MAPT (0.47) | HCAR2MAPTALDH1A1CYP3A4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8779192-B2 | Process of preparing an alkylamine derivative | KOLON LIFE SCIENCE, INC. | 2014-07-15 | — | — | US | claimed |
| US-20120046494-A1 | METHOD OF PREPARING AN ALKYLAMINE DERIVATIVE | KOLON LIFE SCIENCE, INC. (KR) | 2012-02-23 | — | — | US | claimed |
| US-9758471-B2 | Process for the preparation of 4-dimethylaminocrotonic acid | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2017-09-12 | — | — | US | disclosed |
| US-20170107172-A1 | PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2017-04-20 | — | — | US | disclosed |
| EP-3148977-A1 | PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID | Sun Pharmaceutical Industries Ltd (IN) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015186065-A1 | PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2015-12-10 | — | — | WO | disclosed |
| US-8779192-B2 | Process of preparing an alkylamine derivative | KOLON LIFE SCIENCE, INC. | 2014-07-15 | — | — | US | disclosed |
| US-20120046494-A1 | METHOD OF PREPARING AN ALKYLAMINE DERIVATIVE | KOLON LIFE SCIENCE, INC. (KR) | 2012-02-23 | — | — | US | disclosed |
| US-7126025-B2 | Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines | WYETH (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1585479-A2 | SYNTHESIS OF 4AMINO-2-BUTENOYL CHLORIDES AND THEIR USE IN THE PREPARATION OF 3-CYANO QUINOLINES | Wyeth (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040162442-A1 | Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines | WYETH (US) | 2004-08-19 | — | — | US | disclosed |
| WO-2004066919-A2 | SYNTHESIS OF 4AMINO-2-BUTENOYL CHLORIDES AND THEIR USE IN THE PREPARATION OF 3-CYANO QUINOLINES | WYETH (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046494-A1 | METHOD OF PREPARING AN ALKYLAMINE DERIVATIVE | INMT, PNMT, ALKBH2 | HCAR2 3189/4885MAPT 4277/4885ALDH1A1 802/4885 |
| US-20170107172-A1 | PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID | EGFR, MET, ABL1 | HCAR2 639/4885MAPT 3324/4885ALDH1A1 452/4885 |
| US-20040162442-A1 | Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines | HBS1L, ATXN2L, ASNS | HCAR2 2952/4885MAPT 4587/4885ALDH1A1 1106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.