Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.82 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.82 |
| ▸ | LTA4H | P09960 | 1/20 | 0.64 |
| ▸ | ABAT | P80404 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10427401 | 0.95 | ESR1 (0.74) | ESR1ESR2LTA4HABATKEAP1 | |
| SCHEMBL2969737 | 0.91 | ESR1 (1.00) | ESR1ESR2LTA4HABATKEAP1 | |
| SCHEMBL36454 | 0.91 | ESR1 (1.00) | ESR1ESR2LTA4HABATKEAP1 | |
| SCHEMBL1121382 | 0.88 | ESR1 (0.82) | ESR1ESR2LTA4HABATKEAP1 | |
| Resorcinol SCHEMBL10603853 | 0.87 | ESR1 (0.70) | ESR1ESR2LTA4HABATKEAP1 | |
| SCHEMBL833872 | 0.82 | ESR1 (0.82) | ESR1ESR2ABATKEAP1ABL1 | |
| SCHEMBL10434816 | 0.82 | ESR1 (0.82) | ESR1ESR2ABATKEAP1ABL1 | |
| SCHEMBL22451383 | 0.82 | ESR1 (0.82) | ESR1ESR2ABATKEAP1ABL1 | |
| Formaldehyde SCHEMBL6014338 | 0.82 | ESR1 (0.82) | ESR1ESR2ABATKEAP1CA2 | |
| SCHEMBL3174260 | 0.82 | ESR1 (0.82) | ESR1ESR2ABATKEAP1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150020944-A1 | PNEUMATIC TIRE HAVING A SINGLE CARCASS PLY REINFORCED WITH POLYESTER CORDS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2015-01-22 | — | — | US | disclosed |
| EP-2826641-A1 | Pneumatic tire having a single carcass ply reinforced with polyester cords | The Goodyear Tire & Rubber Company (US) | 2015-01-21 | — | — | EP | disclosed |
| EP-2692548-A2 | Pneumatic tire comprising an embedded rigid structure and method of manufacturing | The Goodyear Tire & Rubber Company (US) | 2014-02-05 | — | — | EP | disclosed |
| US-20140027030-A1 | ADHESIVE BONDING FOR A PNEUMATIC TIRE | FRANTZEN ANDREAS (DE) | 2014-01-30 | — | — | US | disclosed |
| EP-1491365-B1 | Polyester cords and their use in runflat tires | GOODYEAR TIRE & RUBBER (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-2123481-B1 | High twist polyester carcass ply for a pneumatic tire | GOODYEAR TIRE & RUBBER (US) | 2011-06-29 | — | — | EP | disclosed |
| EP-2065220-B1 | Pneumatic tire | GOODYEAR TIRE & RUBBER (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-2033811-B1 | Pneumatic tire | GOODYEAR TIRE & RUBBER (US) | 2010-09-22 | — | — | EP | disclosed |
| EP-2123481-A1 | High twist polyester carcass ply for a pneumatic tire | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090277554-A1 | HIGH TWIST POLYESTER CARCASS PLY FOR A PNEUMATIC TIRE | DONCKELS YVES | 2009-11-12 | — | — | US | disclosed |
| US-20070277920-A1 | Agricultural or industrial tire with polyester cord | THE GOODYEAR TIRE & RUBBER COMPANY | 2007-12-06 | — | — | US | disclosed |
| US-20070209751-A1 | Polyester cord and their use in runflat tires | THE GOODYEAR TIRE & RUBBER COMPANY | 2007-09-13 | — | — | US | disclosed |
| US-20070187030-A1 | Agricultural or industrial tire with reinforced rubber composition | THE GOODYEAR TIRE & RUBBER COMPANY | 2007-08-16 | — | — | US | disclosed |
| EP-1630267-A1 | Method of producing a reinforced rubber component | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20060033231-A1 | Monofilament reinforced rubber component and method of producing | REUTER RENE F | 2006-02-16 | — | — | US | disclosed |
| EP-1559587-A2 | Agricultural or industrial tire with reinforced rubber composition | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20050139302-A1 | Agricultural or industrial tire with polyester cord | REUTER RENE F (LU) | 2005-06-30 | — | — | US | disclosed |
| US-20040261928-A1 | Comprising a casing having at least one component reinforced with polyester cord having a polyepoxide disposed on a surface of cord, a rubber tread disposed radially outwardly of the casing | IMHOFF SERGE JULIEN AUGUSTE (LU) | 2004-12-30 | — | — | US | disclosed |
| US-20040182486-A1 | Agricultural or industrial tire with reinforced rubber composition | BERNARD CARLO (LU) | 2004-09-23 | — | — | US | disclosed |
| EP-1442900-A2 | Agricultural or industrial tire with polyester cord | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2004-08-04 | — | — | EP | disclosed |