Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.46 |
| ▸ | HTR1D | P28221 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 4/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868677 | 1.00 | SIGMAR1 (0.51) | SIGMAR1TRPM8HTR1DSLC6A4MEN1 | |
| SCHEMBL6459479 | 0.87 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2APOLBMAPT | |
| SCHEMBL6459469 | 0.87 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2APOLBMAPT | |
| SCHEMBL13793201 | 0.87 | MCHR1 (0.53) | SIGMAR1TRPM8HTR1DSLC6A4MEN1 | |
| SCHEMBL6875686 | 0.83 | SIGMAR1 (0.52) | SIGMAR1TRPM8HTR1DSLC6A4MEN1 | |
| SCHEMBL6875682 | 0.83 | SIGMAR1 (0.52) | SIGMAR1TRPM8HTR1DSLC6A4MEN1 | |
| SCHEMBL6872998 | 0.80 | MCHR1 (0.51) | SIGMAR1KDM4E | |
| SCHEMBL6872993 | 0.80 | MCHR1 (0.51) | SIGMAR1KDM4E | |
| SCHEMBL6874760 | 0.80 | SIGMAR1 (0.49) | SIGMAR1TRPM8HTR1DSLC6A4MEN1 | |
| SCHEMBL6874755 | 0.80 | SIGMAR1 (0.49) | SIGMAR1TRPM8HTR1DSLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |