Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874760 | 1.00 | SIGMAR1 (0.49) | SIGMAR1TRPM8MEN1KMT2AHTR1D | |
| SCHEMBL13793201 | 0.88 | MCHR1 (0.53) | SIGMAR1TRPM8MEN1KMT2AHTR1D | |
| SCHEMBL6458400 | 0.86 | APP (0.49) | SIGMAR1BCHEACHEPOLBAPP | |
| SCHEMBL6458392 | 0.86 | APP (0.49) | SIGMAR1BCHEACHEPOLBAPP | |
| SCHEMBL6874757 | 0.85 | TRPM8 (0.38) | TRPM8MEN1KMT2AHTR1DBCHE | |
| SCHEMBL6875686 | 0.83 | SIGMAR1 (0.52) | SIGMAR1TRPM8MEN1KMT2AHTR1D | |
| SCHEMBL6875682 | 0.83 | SIGMAR1 (0.52) | SIGMAR1TRPM8MEN1KMT2AHTR1D | |
| SCHEMBL13795324 | 0.81 | MCHR1 (0.48) | SIGMAR1TRPM8MEN1KMT2AHTR1D | |
| SCHEMBL6868677 | 0.80 | SIGMAR1 (0.51) | SIGMAR1TRPM8MEN1KMT2AHTR1D | |
| SCHEMBL6868681 | 0.80 | SIGMAR1 (0.51) | SIGMAR1TRPM8MEN1KMT2AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |