Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873242 | 1.00 | MCHR1 (0.37) | MCHR1HTTGLAADRA2AHRH1 | |
| SCHEMBL6874211 | 0.92 | MCHR1 (0.41) | MCHR1HTTADRA2AHRH1HTR2B | |
| SCHEMBL6874218 | 0.92 | MCHR1 (0.41) | MCHR1HTTADRA2AHRH1HTR2B | |
| SCHEMBL6868958 | 0.90 | EPHX2 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6868955 | 0.90 | EPHX2 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6880295 | 0.88 | ALOX12 (0.44) | MCHR1HTTGLAADRA2AHRH1 | |
| SCHEMBL6875325 | 0.88 | ALOX12 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6880292 | 0.88 | ALOX12 (0.44) | MCHR1HTTGLAADRA2AHRH1 | |
| SCHEMBL6875329 | 0.88 | ALOX12 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6457203 | 0.84 | MCHR1 (0.40) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |