Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 16/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 11/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869001 | 1.00 | MCHR1 (0.44) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6879662 | 0.90 | MCHR1 (0.40) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6879668 | 0.90 | MCHR1 (0.40) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6880533 | 0.90 | ALOX12 (0.53) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6880536 | 0.90 | ALOX12 (0.53) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6877748 | 0.90 | MCHR1 (0.46) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6877751 | 0.90 | MCHR1 (0.46) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6877832 | 0.89 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6880188 | 0.89 | ALDH1A1 (0.42) | MCHR1ALOX12ADRA2AHRH1HTR2B | |
| SCHEMBL6877825 | 0.89 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |