Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6861092 | 0.92 | SLC6A4 (0.36) | SLC6A4SLC6A3SLC6A2MCHR1LMNA | |
| SCHEMBL6870938 | 0.92 | SLC6A4 (0.36) | SLC6A4SLC6A3SLC6A2MCHR1LMNA | |
| SCHEMBL6861086 | 0.92 | SLC6A4 (0.36) | SLC6A4SLC6A3SLC6A2MCHR1LMNA | |
| SCHEMBL5208920 | 0.81 | SMN1; SMN2 (0.33) | GAA | |
| Hydrochloric Acid SCHEMBL4868815 | 0.80 | SMN1; SMN2 (0.32) | GAA | |
| SCHEMBL4870450 | 0.77 | TSHR (0.33) | GAA | |
| Hydrochloric Acid SCHEMBL4868298 | 0.76 | TSHR (0.33) | — | |
| SCHEMBL6297680 | 0.76 | METAP1 (0.36) | SLC6A4SLC6A2MCHR1LMNAGAA | |
| SCHEMBL4870022 | 0.74 | CHRNB2 (0.45) | — | |
| SCHEMBL12020026 | 0.73 | PDE4A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069106-B1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0799819-B1 | 1-Dimethylaminomethyl 2-phenyl cycloalk-2-ene derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-1069106-A2 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 2001-01-17 | — | — | EP | disclosed |
| EP-0983994-A2 | Pharmaceutically-active dimethyl-(3-aryl-but-3-enyl)-amine compounds | Grünenthal GmbH (DE) | 2000-03-08 | — | — | EP | disclosed |
| EP-0799819-A1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |