Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4868331 | 0.99 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 | |
| SCHEMBL4870297 | 0.96 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4871251 | 0.95 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 | |
| SCHEMBL4865396 | 0.95 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 | |
| SCHEMBL4865383 | 0.95 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4868728 | 0.94 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4868718 | 0.94 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 | |
| SCHEMBL5208920 | 0.77 | SMN1; SMN2 (0.33) | CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4861396 | 0.77 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA3ALDH1A1CYP1A2 | |
| SCHEMBL23909935 | 0.76 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA3CHRNA7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384961-B2 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2008-06-10 | — | — | US | claimed |
| EP-1572653-B1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | GRUENENTHAL GMBH (DE) | 2007-11-21 | — | — | EP | claimed |
| JP-2006523182-A | — | — | 2006-10-12 | — | — | JP | claimed |
| US-20060025456-A1 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2006-02-02 | — | — | US | claimed |
| EP-1572653-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2005-09-14 | — | — | EP | claimed |
| WO-2004063161-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2004-07-29 | — | — | WO | claimed |
| US-7384961-B2 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2008-06-10 | — | — | US | disclosed |
| EP-1572653-B1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | GRUENENTHAL GMBH (DE) | 2007-11-21 | — | — | EP | disclosed |
| US-20060025456-A1 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2006-02-02 | — | — | US | disclosed |
| EP-1572653-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004063161-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025456-A1 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | OPRK1, OPRM1, HTR1A | CHRNB2 256/4885CHRNA4 133/4885CHRNA3 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.