Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511688 | 0.87 | POLB (0.61) | POLBMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL2523994 | 0.77 | POLB (0.72) | POLBMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL14636509 | 0.75 | POLB (0.50) | POLBMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6873313 | 0.73 | KMT2A (0.38) | POLBKMT2AMEN1 | |
| SCHEMBL14477946 | 0.72 | POLB (0.73) | POLBMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL25192028 | 0.70 | POLB (0.45) | POLBMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL2328642 | 0.69 | MAPT (0.47) | POLBMAPTSMN1; SMN2GAAKMT2A | |
| SCHEMBL15082372 | 0.68 | MEN1 (0.59) | POLBMAPTSMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL688492 | 0.67 | POLB (1.00) | POLBMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7951946 | 0.67 | POLB (0.66) | POLBMAPTSMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395560-A1 | 2-OXO-PIPERIDINYL- AND 2-OXO-AZEPANYL ALKANOIC ACID DERIVATIV ES FOR THE TREATMENT OF EPILEPSY AND OTHER NEUROLOGICAL DISORDERS | UCB, S.A. (BE) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094787-A1 | 2-OXO-PIPERIDINYL- AND 2-OXO-AZEPANYL ALKANOIC ACID DERIVATIV ES FOR THE TREATMENT OF EPILEPSY AND OTHER NEUROLOGICAL DISORDERS | UCB, S.A. (BE) | 2002-11-28 | — | — | WO | disclosed |