Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293964 | 0.81 | POLB (0.67) | POLBSMN1; SMN2MAPTHTTCASP1 | |
| SCHEMBL9057201 | 0.81 | BRD4 (0.50) | SMN1; SMN2MAPTHTTGAAALDH1A1 | |
| SCHEMBL25192028 | 0.81 | POLB (0.45) | POLBSMN1; SMN2MAPTHTTCASP1 | |
| SCHEMBL27001822 | 0.77 | SMN1; SMN2 (0.57) | POLBSMN1; SMN2MAPTHTTL3MBTL1 | |
| SCHEMBL20481291 | 0.77 | POLB (0.42) | POLBSMN1; SMN2MAPTHTTL3MBTL1 | |
| SCHEMBL13624405 | 0.76 | POLB (0.40) | POLBMAPTGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2328642 | 0.76 | MAPT (0.47) | POLBSMN1; SMN2MAPTCASP1CASP7 | |
| SCHEMBL6869171 | 0.75 | POLB (0.50) | POLBSMN1; SMN2MAPTHTTGAA | |
| SCHEMBL21107682 | 0.74 | POLB (0.58) | POLBSMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL16759091 | 0.73 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2MAPTHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |
| EP-2734529-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013010380-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-01-24 | — | — | WO | disclosed |