Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.54 |
| ▸ | KDM6B | O15054 | 1/20 | 0.54 |
| ▸ | KDM5C | P41229 | 1/20 | 0.54 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.54 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14064494 | 0.84 | KDM4E (0.51) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL16711033 | 0.81 | KDM4E (0.48) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL22000176 | 0.81 | KDM4E (0.48) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL6867494 | 0.80 | MLYCD (0.38) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL29894587 | 0.75 | KDM4E (0.86) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL70279 | 0.75 | KDM4E (0.86) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL30378954 | 0.75 | KDM4E (0.58) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL1759313 | 0.75 | KDM4E (0.58) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL200699 | 0.74 | KDM4E (0.62) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL1180311 | 0.74 | KDM4E (0.62) | KDM4EKDM4CKDM6BKDM5CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| CN-1486314-A | Aminotriazolopyridine derivatives as adenosine receptor ligands | - | 2004-03-31 | — | — | CN | disclosed |
| EP-1347974-A1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |
| WO-2002048145-A1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-20 | — | — | WO | disclosed |