Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 12/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777780 | 0.86 | PROKR1 (0.44) | MLYCDPROKR1 | |
| SCHEMBL6869715 | 0.80 | KDM4E (0.54) | SMN1; SMN2NPC1RAB9AKDM4EKDM6B | |
| SCHEMBL29581703 | 0.78 | MLYCD (0.42) | MLYCDPROKR1KDM4EKDM6BKDM5C | |
| SCHEMBL12672262 | 0.78 | MLYCD (0.42) | MLYCDPROKR1KDM4EKDM6BKDM5C | |
| SCHEMBL305494 | 0.77 | GABRP (0.54) | MLYCDKDM4EKDM6BKDM5CKDM4C | |
| SCHEMBL14222120 | 0.77 | MLYCD (0.41) | MLYCDKDM4EKDM6BKDM5CKDM4C | |
| SCHEMBL2145070 | 0.77 | KCNK3 (0.46) | MLYCDPROKR1KDM4EKDM6BKDM5C | |
| SCHEMBL305997 | 0.77 | CYP11B1 (0.43) | MLYCDPKMRAB9APROKR1KDM4E | |
| SCHEMBL5775191 | 0.77 | MLYCD (0.41) | MLYCDKDM4EKDM6BKDM5CKDM4C | |
| SCHEMBL1886467 | 0.77 | MLYCD (0.44) | MLYCDKDM4EKDM6BKDM5CKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| CN-1486314-A | Aminotriazolopyridine derivatives as adenosine receptor ligands | - | 2004-03-31 | — | — | CN | disclosed |
| EP-1347974-A1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |
| WO-2002048145-A1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-20 | — | — | WO | disclosed |