Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 4/20 | 0.56 |
| ▸ | CLK2 | P49760 | 3/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.44 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12332351 | 0.79 | PARP1 (0.57) | PARP1ACVR1SLC2A1IP6K1IP6K3 | |
| SCHEMBL2116665 | 0.78 | SLC2A1 (0.66) | PARP1SLC2A1IP6K1KDM4EALDH1A1 | |
| SCHEMBL7976876 | 0.77 | TGFBR1 (0.58) | ERN1PARP1ACVR1SLC2A1IP6K1 | |
| SCHEMBL1675115 | 0.74 | CLK1 (0.61) | CLK1CLK2CLK4DYRK1BDYRK1A | |
| SCHEMBL1675116 | 0.74 | CLK4 (0.72) | CLK1CLK2CLK4DYRK1BDYRK1A | |
| SCHEMBL1179094 | 0.73 | ERN1 (0.50) | CLK1CLK2CLK4DYRK1BDYRK1A | |
| SCHEMBL9911097 | 0.73 | IP6K1 (0.66) | PARP1ACVR1SLC2A1IP6K1IP6K3 | |
| SCHEMBL1675185 | 0.72 | CLK4 (0.65) | CLK1CLK2CLK4DYRK1BDYRK1A | |
| SCHEMBL1675053 | 0.72 | CLK1 (0.64) | CLK1CLK2CLK4DYRK1BDYRK1A | |
| SCHEMBL1675054 | 0.72 | CLK4 (1.00) | CLK1CLK2CLK4DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |