Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116665 | 0.78 | SLC2A1 (0.66) | KMT2AATMKDM4EALDH1A1HPGD | |
| SCHEMBL6869826 | 0.77 | CLK1 (0.56) | TGFBR1ACVR1KDM4EALDH1A1HPGD | |
| SCHEMBL28036066 | 0.75 | ACVR1 (0.64) | TGFBR1ACVR1PARP1IP6K1IP6K3 | |
| SCHEMBL21083337 | 0.74 | TGFBR1 (1.00) | TGFBR1ACVR1PARP1IP6K1IP6K3 | |
| SCHEMBL27686802 | 0.73 | TSHR (0.65) | KMT2AATMKDM4EALDH1A1HPGD | |
| SCHEMBL3740005 | 0.72 | ACVR1 (0.74) | TGFBR1ACVR1PARP1IP6K1IP6K3 | |
| SCHEMBL7980737 | 0.72 | ACVR1 (0.67) | TGFBR1ACVR1PARP1PIK3CDIP6K1 | |
| SCHEMBL4367861 | 0.72 | CLK4 (0.55) | ALDH1A1HPGDMAPK1 | |
| SCHEMBL8622180 | 0.72 | ACVR1 (0.73) | ACVR1PARP1SLC2A1IP6K1IP6K3 | |
| SCHEMBL9272871 | 0.71 | ACVR1 (0.56) | TGFBR1ACVR1PARP1IP6K1IP6K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |