Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 7/20 | 0.49 |
| ▸ | FNTB | P49356 | 7/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872833 | 0.89 | FNTA (0.49) | FNTAFNTBCNR1ALDH1A1CYP1A2 | |
| SCHEMBL6861981 | 0.83 | ALDH1A1 (0.42) | FNTAFNTBCNR1ALDH1A1CYP1A2 | |
| SCHEMBL4144550 | 0.82 | FNTA (0.51) | FNTAFNTBCNR1CYP1A2CYP3A4 | |
| Oxalic Acid SCHEMBL7701815 | 0.80 | FNTA (0.49) | FNTAFNTBCNR1CYP1A2CYP3A4 | |
| SCHEMBL6870737 | 0.76 | FNTA (0.50) | FNTAFNTBCNR1CYP3A4HSD17B10 | |
| SCHEMBL27251471 | 0.71 | FNTA (0.66) | FNTAFNTBCNR1CYP3A4HSD17B10 | |
| SCHEMBL14588476 | 0.71 | FNTA (0.64) | FNTAFNTBCYP3A4HSD17B10KMT2A | |
| SCHEMBL6170916 | 0.71 | FNTA (0.55) | FNTAFNTBCNR1HSD17B10KMT2A | |
| SCHEMBL6010160 | 0.69 | FNTA (0.78) | FNTAFNTBCYP3A4 | |
| SCHEMBL14588475 | 0.69 | FNTA (0.62) | FNTAFNTBCNR1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106610-B1 | Farnesyl transferase inhibiting 2-quinolone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-16 | — | — | EP | disclosed |
| EP-1019395-B1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-30 | — | — | EP | disclosed |
| EP-1106610-A1 | Farnesyl transferase inhibiting 2-quinolone derivatives | Janssen Pharmaceutica N.V. (BE) | 2001-06-13 | — | — | EP | disclosed |
| US-5968952-A | ANTITUMOR AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-10-19 | — | — | US | disclosed |