Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 7/20 | 0.41 |
| ▸ | FNTB | P49356 | 7/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869864 | 0.83 | FNTA (0.49) | ALDH1A1KDM4EFNTAFNTBPTGER4 | |
| SCHEMBL1538260 | 0.83 | FNTA (0.56) | ALDH1A1FNTAFNTBCYP3A4HSD17B10 | |
| SCHEMBL30419724 | 0.83 | FNTA (0.56) | ALDH1A1FNTAFNTBCYP3A4HSD17B10 | |
| SCHEMBL6872833 | 0.82 | FNTA (0.49) | ALDH1A1FNTAFNTBPTGER4CYP1A2 | |
| SCHEMBL6164984 | 0.81 | BRD4 (0.44) | FNTAFNTB | |
| SCHEMBL5509068 | 0.77 | MAPT (0.46) | FNTAFNTBCYP3A4HSD17B10CNR1 | |
| SCHEMBL5657960 | 0.76 | FNTA (0.48) | ALDH1A1FNTAFNTBHSD17B10KMT2A | |
| Oxalic Acid SCHEMBL7701815 | 0.76 | FNTA (0.49) | FNTAFNTBCYP1A2CYP3A4CNR1 | |
| SCHEMBL6862062 | 0.76 | FNTA (0.43) | ALDH1A1LMNAFNTAFNTBCYP3A4 | |
| SCHEMBL4144550 | 0.75 | FNTA (0.51) | FNTAFNTBCYP1A2CYP3A4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106610-B1 | Farnesyl transferase inhibiting 2-quinolone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-16 | — | — | EP | disclosed |
| EP-1019395-B1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-30 | — | — | EP | disclosed |
| EP-1106610-A1 | Farnesyl transferase inhibiting 2-quinolone derivatives | Janssen Pharmaceutica N.V. (BE) | 2001-06-13 | — | — | EP | disclosed |
| US-5968952-A | ANTITUMOR AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-10-19 | — | — | US | disclosed |