Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.40 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872781 | 0.91 | TACR1 (0.74) | TACR1GPBAR1 | |
| SCHEMBL4131710 | 0.85 | TACR1 (0.82) | TACR1SGMS2 | |
| SCHEMBL6016586 | 0.82 | TACR1 (0.64) | TACR1 | |
| SCHEMBL6868287 | 0.80 | TACR1 (0.63) | TACR1GPBAR1 | |
| SCHEMBL5761333 | 0.77 | TACR1 (0.56) | TACR1 | |
| SCHEMBL6872159 | 0.76 | TACR1 (0.49) | TACR1GPBAR1 | |
| SCHEMBL4125271 | 0.76 | TACR1 (1.00) | TACR1SGMS2 | |
| SCHEMBL6637377 | 0.75 | TACR1 (0.83) | TACR1 | |
| SCHEMBL6862358 | 0.75 | TACR1 (0.72) | TACR1 | |
| SCHEMBL6016699 | 0.74 | TACR1 (0.65) | TACR1GPBAR1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171419-B1 | BIPHENYL DERIVATIVES AS ANTAGONISTS OF THE NEUROKININE-1 RECEPTOR | HOFFMANN LA ROCHE (CH) | 2004-12-29 | — | — | EP | claimed |