Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870223 | 1.00 | RIPK1 (0.42) | RIPK1TAS2R14SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6078402 | 0.90 | RIPK1 (0.41) | RIPK1TAS2R14SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6077626 | 0.90 | RIPK1 (0.41) | RIPK1TAS2R14SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6870326 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3ALDH1A1KDM4E | |
| SCHEMBL6870321 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3ALDH1A1KDM4E | |
| SCHEMBL6877631 | 0.84 | ALDH1A1 (0.48) | RIPK1TAS2R14SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL6877629 | 0.84 | ALDH1A1 (0.48) | RIPK1TAS2R14SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL3682001 | 0.81 | TDP1 (0.39) | RIPK1TAS2R14ALDH1A1TDP1 | |
| SCHEMBL3681999 | 0.81 | TDP1 (0.39) | RIPK1TAS2R14ALDH1A1TDP1 | |
| SCHEMBL5797871 | 0.81 | TDP1 (0.39) | RIPK1TAS2R14ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777440-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-17 | — | — | US | disclosed |
| US-20030176495-A1 | HIV Integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176495-A1 | HIV Integrase inhibitors | MAPT, RIF1, HPRT1 | RIPK1 1438/4885TAS2R14 4569/4885SLC6A2 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.