Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 7/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31236792 | 1.00 | MAPT (0.50) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL272745 | 0.85 | — | — | |
| SCHEMBL3392101 | 0.85 | HRH3 (0.43) | LMNAERN1 | |
| Bromide SCHEMBL9249645 | 0.83 | CYP3A4 (0.50) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL21352581 | 0.83 | HRH3 (0.41) | LMNASMN1; SMN2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL15827843 | 0.80 | MAPT (0.48) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL6881081 | 0.78 | CYP2A6 (0.62) | CYP11B2CYP19A1CYP3A4ERN1KIF11 | |
| SCHEMBL6364651 | 0.77 | MAOB (0.40) | LMNACYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL27594226 | 0.77 | LMNA (0.44) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL5226620 | 0.76 | MAPT (0.55) | MAPTLMNACYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |