Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133980 | 0.91 | PSEN1 (0.36) | HDAC1HDAC8PSEN1PSEN2APH1B | |
| SCHEMBL5133406 | 0.88 | PSEN1 (0.37) | HDAC1HDAC8PSEN1PSEN2APH1B | |
| SCHEMBL5131094 | 0.83 | MAOB (0.39) | HDAC1HDAC8PSEN1PSEN2APH1B | |
| SCHEMBL5132869 | 0.83 | MAOB (0.39) | HDAC1HDAC8PSEN1PSEN2APH1B | |
| SCHEMBL5131353 | 0.79 | KIF11 (0.32) | HDAC1HDAC8PSEN1PSEN2APH1B | |
| SCHEMBL5133365 | 0.79 | LSS (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5133388 | 0.78 | HRH3 (0.45) | KCNH2 | |
| SCHEMBL5130102 | 0.78 | KIF11 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5131020 | 0.78 | LSS (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5133263 | 0.77 | SIGMAR1 (0.45) | KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-B1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2004-12-29 | — | — | EP | disclosed |