Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453156 | 0.78 | CA1 (0.39) | CA12CA1CA2CA7CA13 | |
| SCHEMBL29571087 | 0.78 | CA1 (0.39) | CA12CA1CA2CA7CA13 | |
| SCHEMBL29671274 | 0.76 | CA12 (0.38) | CA12CA1CA2CA7CA13 | |
| SCHEMBL6871891 | 0.76 | LMNA (0.40) | CA12CA1CA2CES2CES1 | |
| SCHEMBL29671276 | 0.76 | CA1 (0.54) | CA12CA1CA2CA7CA13 | |
| SCHEMBL7245664 | 0.76 | CA12 (0.38) | CA12CA1CA2CA7CA13 | |
| SCHEMBL4581458 | 0.76 | CA1 (0.54) | CA12CA1CA2CA7CA13 | |
| SCHEMBL1535900 | 0.76 | CA12 (0.38) | CA12CA1CA2CA7CA13 | |
| SCHEMBL5865794 | 0.73 | CA12 (0.35) | CA12CA1CA2CA7CA13 | |
| SCHEMBL6272297 | 0.73 | CA1 (0.35) | CA12CA1CA2CA7CA13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149094-B1 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2004-04-21 | — | — | EP | disclosed |
| US-6376491-B1 | BENZOFURAN DERIVATIVES FOR TREATMENT OR PREVENTION OF MYCOSIS IN MAMMALS | BASILEA PHARMACEUTICA AG (CH) | 2002-04-23 | — | — | US | disclosed |
| EP-1149094-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | Basilea Pharmaceutica AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000037464-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2000-06-29 | — | — | WO | disclosed |