Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.57 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.53 |
| ▸ | PI4KA | P42356 | 2/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.48 |
| ▸ | AHCY | P23526 | 5/20 | 0.45 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.45 |
| ▸ | SLC28A2 | O43868 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | GAPDH | P04406 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298535 | 0.84 | ADORA2A (0.53) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL28156591 | 0.76 | ADORA2A (0.64) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL1078828 | 0.76 | ADORA2A (0.64) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL19859805 | 0.75 | ADORA2A (0.62) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL22474991 | 0.74 | ADORA2A (0.64) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL19692161 | 0.74 | ADORA2A (0.58) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL11040343 | 0.74 | ADORA2A (0.58) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL8672664 | 0.74 | ADORA2A (0.67) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL8943715 | 0.73 | ADORA2A (0.57) | ADORA2API4K2API4KAPI4K2BPI4KB | |
| SCHEMBL19859736 | 0.73 | ADORA2A (0.57) | ADORA2API4K2API4KAPI4K2BPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6822089-B1 | FROM CORRESPONDING RIBONUCLEOSIDES BY FORMING 3-TERT-BUTYLPHENOXYTHIOCARBONYL DERIVATIVES AND EFFECTING RADICAL DEOXYGENATION; SOLID PHASE SYNTHESIS | ISIS PHARMACEUTICALS, INC. | 2004-11-23 | — | — | US | disclosed |
| EP-1366056-A2 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-1366056-A4 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2001073095-A2 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | WO | disclosed |