Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.46 |
| ▸ | PI4KA | P42356 | 2/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.46 |
| ▸ | AHCY | P23526 | 4/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.43 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.41 |
| ▸ | SLC28A2 | O43868 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | GAPDH | P04406 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6871011 | 0.84 | ADORA2A (0.57) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL19859805 | 0.73 | ADORA2A (0.62) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL1078828 | 0.72 | ADORA2A (0.64) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL28156591 | 0.72 | ADORA2A (0.64) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL23171267 | 0.71 | ADORA2A (0.60) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL11703712 | 0.71 | ADORA2A (0.54) | ADORA2AADORA3AHCYADORA2BHSP90B1 | |
| SCHEMBL16368295 | 0.71 | ADORA2A (0.60) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL19692161 | 0.70 | ADORA2A (0.58) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL11040343 | 0.70 | ADORA2A (0.58) | ADORA2AADORA3PI4K2API4KAPI4K2B | |
| SCHEMBL8672664 | 0.70 | ADORA2A (0.67) | ADORA2AADORA3PI4K2API4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903079-B2 | Nucleoside compounds and compositions thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| US-20030149050-A1 | Inhibitors of inflammation and reperfusion injury and methods of use thereof | INOTEK CORP. | 2003-08-07 | — | — | US | disclosed |
| US-6534651-B2 | Substituted isoindolinone derivatives | INOTEK PHARMACEUTICALS CORP. | 2003-03-18 | — | — | US | disclosed |
| US-20020095044-A1 | Inhibitors of inflammation and reperfusion injury and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION | 2002-07-18 | — | — | US | disclosed |
| WO-2001077075-A2 | INHIBITORS OF INFLAMMATION AND REPERFUSION INJURY | INOTEK CORPORATION (US) | 2001-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020095044-A1 | Inhibitors of inflammation and reperfusion injury and methods of use thereof | IL1B, PTGS1, MMP8 | ADORA2A 211/4885ADORA3 780/4885PI4K2A 1541/4885 |
| US-20030149050-A1 | Inhibitors of inflammation and reperfusion injury and methods of use thereof | IL1B, PTGS1, MMP8 | ADORA2A 211/4885ADORA3 780/4885PI4K2A 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.