Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | F12 | P00748 | 5/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870348 | 0.89 | ADORA2A (0.56) | ADORA2AKMT2AF12MAPTALDH1A1 | |
| SCHEMBL6870074 | 0.86 | KMT2A (0.48) | ADORA2AKMT2APRNPMAPTALDH1A1 | |
| SCHEMBL6867628 | 0.86 | ADORA2A (0.60) | ADORA2AF12HPGDSF2ALDH1A1 | |
| SCHEMBL7114944 | 0.86 | ADORA2A (0.54) | ADORA2AMAPTALDH1A1LMNA | |
| SCHEMBL6871512 | 0.84 | KMT2A (0.49) | ADORA2AKMT2AF12PRNPF2 | |
| SCHEMBL6869214 | 0.83 | KMT2A (0.46) | ADORA2AKMT2APRNPMAPTALDH1A1 | |
| SCHEMBL6869036 | 0.83 | ADORA2A (0.56) | ADORA2AF12HPGDSF2 | |
| SCHEMBL6869437 | 0.83 | KMT2A (0.47) | ADORA2AKMT2APRNPMAPTALDH1A1 | |
| SCHEMBL6873046 | 0.82 | ADORA2A (0.56) | ADORA2AKMT2APRNPMAPTALDH1A1 | |
| SCHEMBL6870679 | 0.82 | ADORA2A (0.59) | ADORA2AKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |