Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | SPR | P35270 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863814 | 0.85 | ADORA2A (0.67) | ADORA2A | |
| SCHEMBL6867345 | 0.85 | ADORA2A (0.63) | ADORA2A | |
| SCHEMBL6870280 | 0.85 | ADORA2A (0.53) | ADORA2A | |
| SCHEMBL6870030 | 0.84 | ADORA2A (0.66) | ADORA2A | |
| SCHEMBL6863267 | 0.84 | ADORA2A (0.66) | ADORA2A | |
| SCHEMBL6863682 | 0.84 | ADORA2A (0.66) | ADORA2A | |
| SCHEMBL6872004 | 0.84 | ADORA2A (0.47) | ADORA2ACNR2 | |
| SCHEMBL6869731 | 0.82 | ADORA2A (0.45) | ADORA2A | |
| SCHEMBL6870405 | 0.81 | ADORA2A (0.60) | ADORA2A | |
| SCHEMBL6870494 | 0.81 | ADORA2A (0.53) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |