Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873000 | 1.00 | MCHR1 (0.47) | MCHR1ADRA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL6867674 | 0.93 | ADRA2A (0.47) | MCHR1ADRA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL6867680 | 0.93 | ADRA2A (0.47) | MCHR1ADRA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL6878623 | 0.90 | NPSR1 (0.48) | MCHR1ADRA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL6878618 | 0.90 | NPSR1 (0.48) | MCHR1ADRA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL6873523 | 0.90 | ADRA2A (0.46) | MCHR1ADRA2AALDH1A1MEN1KMT2A | |
| SCHEMBL6873527 | 0.90 | ADRA2A (0.46) | MCHR1ADRA2AALDH1A1MEN1KMT2A | |
| SCHEMBL6879376 | 0.89 | KMT2A (0.53) | MCHR1ADRA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL6879371 | 0.89 | KMT2A (0.53) | MCHR1ADRA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL7113893 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2APOLBMAPTHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |