Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872923 | 0.92 | ADORA2A (0.46) | ADORA2ALMNAKMT2AADORA1ADORA3 | |
| SCHEMBL6871404 | 0.90 | ADORA2A (0.51) | ADORA2ATP53 | |
| SCHEMBL6871192 | 0.89 | ADORA2A (0.58) | ADORA2AL3MBTL1TP53MEN1LMNA | |
| SCHEMBL6871992 | 0.83 | ADORA2A (0.58) | ADORA2AMEN1LMNAKMT2AADORA1 | |
| SCHEMBL6870664 | 0.83 | TP53 (0.45) | ADORA2ATP53LMNAKMT2AADORA1 | |
| SCHEMBL6871407 | 0.81 | ADORA2A (0.48) | ADORA2ALMNAKMT2A | |
| SCHEMBL6871380 | 0.81 | MAPT (0.46) | ADORA2ATP53LMNAADORA1ADORA3 | |
| SCHEMBL6871283 | 0.80 | PTGER2 (0.44) | ADORA2AL3MBTL1TP53MEN1LMNA | |
| SCHEMBL6863733 | 0.79 | ADORA2A (0.50) | ADORA2AMEN1KMT2A | |
| SCHEMBL6871493 | 0.79 | ADORA2A (0.66) | ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |