Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | ALPI | P09923 | 1/20 | 0.54 |
| ▸ | ALPG | P10696 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873226 | 1.00 | ALPL (0.54) | ALPLALPIALPGNPC1ALDH1A1 | |
| SCHEMBL27632400 | 0.88 | EPHX1 (0.55) | MAPK8MAPK9MAPK10EPHX1LMNA | |
| SCHEMBL6867353 | 0.84 | MCHR1 (0.46) | ALDH1A1MAPK8EPHX1LMNAMAPK14 | |
| SCHEMBL6867348 | 0.84 | MCHR1 (0.46) | ALDH1A1MAPK8EPHX1LMNAMAPK14 | |
| SCHEMBL6461492 | 0.80 | MAPK8 (0.42) | MAPK8MAPK9MAPK10EPHX1LMNA | |
| SCHEMBL6461498 | 0.80 | MAPK8 (0.42) | MAPK8MAPK9MAPK10EPHX1LMNA | |
| SCHEMBL6457914 | 0.80 | CCR1 (0.43) | MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL6457922 | 0.80 | CCR1 (0.43) | MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL6876213 | 0.80 | GLA (0.48) | ALDH1A1HTTKMT2ALMNAMAPK14 | |
| SCHEMBL6876224 | 0.80 | GLA (0.48) | ALDH1A1HTTKMT2ALMNAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |