Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAST3 | O60307 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867353 | 1.00 | MCHR1 (0.46) | MCHR1MAPK14MAPK11ADRA2AHRH1 | |
| SCHEMBL6458725 | 0.89 | MCHR1 (0.46) | MCHR1MAPK14ADRA2AHRH1HTR2B | |
| SCHEMBL6458736 | 0.89 | MCHR1 (0.46) | MCHR1MAPK14ADRA2AHRH1HTR2B | |
| SCHEMBL27632400 | 0.88 | EPHX1 (0.55) | MCHR1MAPK14MAPK8LMNAEPHX1 | |
| SCHEMBL6462469 | 0.87 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BLMNA | |
| SCHEMBL6462473 | 0.87 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BLMNA | |
| SCHEMBL6873235 | 0.84 | ALPL (0.54) | MAPK14MAPK8ALDH1A1LMNAEPHX1 | |
| SCHEMBL6873226 | 0.84 | ALPL (0.54) | MAPK14MAPK8ALDH1A1LMNAEPHX1 | |
| SCHEMBL6873378 | 0.82 | GAA (0.54) | MCHR1MAPK14ADRA2AHRH1HTR2B | |
| SCHEMBL6873370 | 0.82 | GAA (0.54) | MCHR1MAPK14ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |