Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12019504 | 0.89 | CYP2C9 (0.36) | LIPGCYP2C9ADRA1AHRH1MAOA | |
| SCHEMBL1815304 | 0.88 | GRM5 (0.36) | LIPGCYP2C9ADRA1AHRH1MAOA | |
| SCHEMBL1815874 | 0.86 | IKZF1 (0.38) | LIPGCYP2C9ADRA1AHRH1MAOA | |
| SCHEMBL6877162 | 0.84 | CYP2C9 (0.38) | CYP2C9ADRA1AHRH1MAOAGRM5 | |
| SCHEMBL6872988 | 0.83 | GRM5 (0.35) | LIPGCYP2C9ADRA1AHRH1MAOA | |
| SCHEMBL6872983 | 0.82 | RORC (0.35) | CYP2C9ADRA1AHRH1MAOAGRM5 | |
| SCHEMBL6873281 | 0.82 | CYP2C9 (0.34) | LIPGCYP2C9ADRA1AHRH1MAOA | |
| SCHEMBL1817330 | 0.82 | CYP2C9 (0.39) | CYP2C9ADRA1AHRH1GRM5GRM1 | |
| SCHEMBL12004426 | 0.80 | RORC (0.39) | CYP2C9ADRA1AHRH1GRM5GRM1 | |
| SCHEMBL12004121 | 0.79 | LIPG (0.38) | LIPGCYP2C9ADRA1AHRH1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507521-B2 | Heterocyclic derivatives | Merck Sharp + Dohme B.V. (NL) | 2013-08-13 | — | — | US | disclosed |
| US-8507521-B2 | Heterocyclic derivatives | Merck Sharp + Dohme B.V. (NL) | 2013-08-13 | — | — | US | disclosed |
| US-20120220622-A1 | HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-08-30 | — | — | US | disclosed |
| US-20120220622-A1 | HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-08-30 | — | — | US | disclosed |
| WO-2011051490-A2 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220622-A1 | HETEROCYCLIC DERIVATIVES | GRIN2C, GRIN3A, GRIN2D | LIPG 4809/4885CYP2C9 569/4885ADRA1A 715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.