Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 10/20 | 0.40 |
| ▸ | NOS1 | P29475 | 9/20 | 0.40 |
| ▸ | NOS3 | P29474 | 7/20 | 0.40 |
| ▸ | ATP4A | P20648 | 6/20 | 0.39 |
| ▸ | ATP4B | P51164 | 6/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 4/20 | 0.39 |
| ▸ | ATP1B1 | P05026 | 4/20 | 0.39 |
| ▸ | ATP1A3 | P13637 | 4/20 | 0.39 |
| ▸ | ATP1B2 | P14415 | 4/20 | 0.39 |
| ▸ | ATP1A2 | P50993 | 4/20 | 0.39 |
| ▸ | ATP1B3 | P54709 | 4/20 | 0.39 |
| ▸ | FXYD2 | P54710 | 4/20 | 0.39 |
| ▸ | ATP1A4 | Q13733 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CBFB | Q13951 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527842 | 1.00 | NOS2 (0.40) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL6487983 | 0.89 | ATP4A (0.44) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL11005003 | 0.88 | ATP4A (0.43) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL5662760 | 0.88 | NOS2 (0.41) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL9526743 | 0.87 | ATP4A (0.42) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL9526670 | 0.87 | ATP4A (0.42) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL11093612 | 0.87 | NOS2 (0.41) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL11089020 | 0.87 | NOS2 (0.41) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL11093614 | 0.87 | NOS2 (0.41) | NOS2NOS1NOS3ATP4AATP4B | |
| SCHEMBL9379675 | 0.86 | ATP4A (0.54) | NOS2NOS1NOS3ATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4628098-A | Including Prevacid (TM) lansoprazole, 2-(3-methyl-4-(2,2,2-trifluoroethoxy)-5-methyl-pyrid-2 -yl)methylsulfinylbenzimidazole; proton pump inhibitors, antiulcer, antisecretory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-12-09 | — | — | US | claimed |
| US-20140328861-A1 | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis | ATOPIX THERAPEUTICS LTD (GB) | 2014-11-06 | — | — | US | disclosed |
| EP-2790696-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | Atopix Therapeutics Limited (GB) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013088109-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | OXAGEN LIMITED (GB) | 2013-06-20 | — | — | WO | disclosed |
| US-20040258621-A1 | Method of treating snoring and other obstructive breathing disorders | SOHNSTEARNS & STERN | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040258621-A1 | Method of treating snoring and other obstructive breathing disorders | HRH2, HRH1, HRH4 | NOS2 424/4885NOS1 362/4885NOS3 426/4885 |
| US-20140328861-A1 | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis | HRH2, HRH1, HRH4 | NOS2 3162/4885NOS1 4105/4885NOS3 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.