Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6883808 | 0.83 | KDR (0.48) | L3MBTL1SMN1; SMN2RAB9AKDRLMNA | |
| SCHEMBL7426305 | 0.83 | RAB9A (0.40) | ANO1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6881417 | 0.82 | LMNA (0.45) | L3MBTL1SMN1; SMN2RAB9ANPC1KDR | |
| SCHEMBL7136553 | 0.80 | LMNA (0.50) | L3MBTL1SMN1; SMN2RAB9ANPC1KDR | |
| SCHEMBL6880000 | 0.80 | RAB9A (0.48) | L3MBTL1SMN1; SMN2RAB9ANPC1KDR | |
| SCHEMBL7147820 | 0.78 | LMNA (0.48) | L3MBTL1SMN1; SMN2RAB9ANPC1KDR | |
| SCHEMBL6881918 | 0.78 | MAPT (0.47) | L3MBTL1SMN1; SMN2RAB9ANPC1KDR | |
| SCHEMBL15145661 | 0.78 | PPID (0.60) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL7143549 | 0.77 | LMNA (0.46) | L3MBTL1SMN1; SMN2RAB9ANPC1KDR | |
| SCHEMBL7301734 | 0.76 | SMN1; SMN2 (0.67) | L3MBTL1SMN1; SMN2RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123283-B1 | THIAZOLE-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-05-06 | — | — | EP | claimed |
| US-6297266-B1 | INHIBIT THE BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES OF CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS. | HOFFMANN-LA ROCHE INC. | 2001-10-02 | — | — | US | claimed |
| EP-1123283-A1 | THIAZOLE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | claimed |
| WO-2000024724-A1 | THIAZOLE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | claimed |
| EP-1123283-B1 | THIAZOLE-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-05-06 | — | — | EP | disclosed |
| US-6297266-B1 | INHIBIT THE BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES OF CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS. | HOFFMANN-LA ROCHE INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1123283-A1 | THIAZOLE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024724-A1 | THIAZOLE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | disclosed |