Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 8/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687761 | 0.92 | CTSA (0.46) | CTSATHRBKDM4EALDH1A1MEN1 | |
| SCHEMBL687486 | 0.89 | ALDH1A1 (0.41) | CTSAKDM4EALDH1A1PTGER3 | |
| SCHEMBL686620 | 0.89 | PTGER3 (0.50) | CTSAKDM4EALDH1A1MAPTPTGER3 | |
| SCHEMBL687794 | 0.88 | MEN1 (0.45) | CTSAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27568079 | 0.86 | KDM4E (0.61) | CTSATHRBKDM4EALDH1A1MEN1 | |
| SCHEMBL686950 | 0.86 | KDM4E (0.61) | CTSATHRBKDM4EALDH1A1MEN1 | |
| SCHEMBL687975 | 0.86 | PTGER3 (0.48) | CTSATHRBKDM4EALDH1A1MAPT | |
| SCHEMBL687280 | 0.84 | POLB (0.43) | CTSAMEN1KMT2ALMNAMAPT | |
| SCHEMBL4698270 | 0.84 | ALDH1A1 (0.44) | CTSAKDM4EALDH1A1MAPTPTGER3 | |
| SCHEMBL687522 | 0.83 | CTSA (0.44) | CTSAKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |