Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874363 | 1.00 | MCHR1 (0.49) | MCHR1ADRA2ASIGMAR1MAOBPYGL | |
| SCHEMBL6874285 | 0.92 | MCHR1 (0.51) | MCHR1ADRA2ASIGMAR1CCR1CCR3 | |
| SCHEMBL6874276 | 0.92 | MCHR1 (0.51) | MCHR1ADRA2ASIGMAR1CCR1CCR3 | |
| SCHEMBL6875053 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ASMYD3 | |
| SCHEMBL6875056 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ASMYD3 | |
| SCHEMBL6875404 | 0.84 | LMNA (0.52) | MCHR1ADRA2ASIGMAR1 | |
| SCHEMBL6875397 | 0.84 | LMNA (0.52) | MCHR1ADRA2ASIGMAR1 | |
| SCHEMBL13793649 | 0.84 | MCHR1 (0.70) | MCHR1ADRA2A | |
| SCHEMBL6872998 | 0.83 | MCHR1 (0.51) | MCHR1ADRA2ASIGMAR1 | |
| SCHEMBL6872993 | 0.83 | MCHR1 (0.51) | MCHR1ADRA2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |