Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875397 | 1.00 | LMNA (0.52) | LMNASIGMAR1MCHR1ADRA2APOLB | |
| SCHEMBL6872998 | 0.93 | MCHR1 (0.51) | LMNASIGMAR1MCHR1ADRA2ANPY5R | |
| SCHEMBL6872993 | 0.93 | MCHR1 (0.51) | LMNASIGMAR1MCHR1ADRA2ANPY5R | |
| SCHEMBL6874276 | 0.91 | MCHR1 (0.51) | LMNASIGMAR1MCHR1ADRA2ANPY5R | |
| SCHEMBL6874285 | 0.91 | MCHR1 (0.51) | LMNASIGMAR1MCHR1ADRA2ANPY5R | |
| SCHEMBL6867900 | 0.90 | MCHR1 (0.51) | LMNASIGMAR1MCHR1ADRA2ANPY5R | |
| SCHEMBL6867894 | 0.90 | MCHR1 (0.51) | LMNASIGMAR1MCHR1ADRA2ANPY5R | |
| SCHEMBL6873544 | 0.90 | NPY5R (0.49) | LMNAMCHR1ADRA2ANPY5RALDH1A1 | |
| SCHEMBL6873540 | 0.90 | NPY5R (0.49) | LMNAMCHR1ADRA2ANPY5RALDH1A1 | |
| SCHEMBL6878551 | 0.89 | SIGMAR1 (0.50) | LMNASIGMAR1MCHR1ADRA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |