Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874820 | 1.00 | MCHR1 (0.51) | MCHR1LMNAALDH1A1ALOX12ADRA2A | |
| SCHEMBL4033750 | 0.86 | MCHR1 (0.59) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL4033667 | 0.86 | MCHR1 (0.59) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6467487 | 0.85 | TP53 (0.47) | MCHR1LMNAALDH1A1ALOX12ADRA2A | |
| SCHEMBL6467491 | 0.85 | TP53 (0.47) | MCHR1LMNAALDH1A1ALOX12ADRA2A | |
| SCHEMBL6877186 | 0.81 | KMT2A (0.46) | LMNAALDH1A1ALOX12KMT2AMEN1 | |
| SCHEMBL6877173 | 0.81 | KMT2A (0.46) | LMNAALDH1A1ALOX12KMT2AMEN1 | |
| SCHEMBL4260723 | 0.78 | LMNA (0.43) | LMNAALDH1A1ALOX12KMT2AMEN1 | |
| SCHEMBL4260719 | 0.78 | LMNA (0.43) | LMNAALDH1A1ALOX12KMT2AMEN1 | |
| SCHEMBL6877520 | 0.78 | NOX1 (0.51) | MCHR1ALDH1A1ADRA2AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |