Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851787 | 1.00 | PKM (0.47) | PKMLMNANOTUMGAAPTK2 | |
| SCHEMBL6874837 | 1.00 | PKM (0.47) | PKMLMNANOTUMGAAPTK2 | |
| SCHEMBL6851821 | 0.81 | PKM (0.50) | PKMLMNANOTUMGAAPTK2 | |
| SCHEMBL6851827 | 0.81 | PKM (0.50) | PKMLMNANOTUMGAAPTK2 | |
| SCHEMBL6852294 | 0.75 | PKM (0.50) | PKMLMNANOTUMGAAPTK2 | |
| SCHEMBL6852296 | 0.75 | PKM (0.50) | PKMLMNANOTUMGAAPTK2 | |
| SCHEMBL6879589 | 0.74 | ATM (0.39) | HDAC4HDAC3HDAC1HDAC2 | |
| SCHEMBL6879587 | 0.74 | ATM (0.39) | HDAC4HDAC3HDAC1HDAC2 | |
| SCHEMBL6879593 | 0.74 | ATM (0.39) | HDAC4HDAC3HDAC1HDAC2 | |
| SCHEMBL10768177 | 0.74 | PKM (0.78) | PKMLMNANOTUMGAAPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |