Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875125 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAHPGDALOX12CDK5 | |
| SCHEMBL6875449 | 0.90 | ALDH1A1 (0.45) | SMN1; SMN2LMNAALOX12ALDH1A1GAA | |
| SCHEMBL6875441 | 0.90 | ALDH1A1 (0.45) | SMN1; SMN2LMNAALOX12ALDH1A1GAA | |
| SCHEMBL6868279 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHPGDCDK5CDK5R1 | |
| SCHEMBL6868267 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHPGDCDK5CDK5R1 | |
| SCHEMBL6871841 | 0.88 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAHPGDALOX12ALDH1A1 | |
| SCHEMBL6871842 | 0.88 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAHPGDALOX12ALDH1A1 | |
| SCHEMBL6868163 | 0.88 | ADRA2A (0.47) | SMN1; SMN2LMNAHPGDALOX12ALDH1A1 | |
| SCHEMBL6868167 | 0.88 | ADRA2A (0.47) | SMN1; SMN2LMNAHPGDALOX12ALDH1A1 | |
| SCHEMBL6879704 | 0.88 | MEN1 (0.53) | SMN1; SMN2LMNAHPGDALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |