Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.51 |
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467019 | 1.00 | ACHE (0.51) | ACHEAPPBCHEBACE1MEN1 | |
| SCHEMBL6459962 | 0.94 | ACHE (0.46) | ACHEAPPBCHEBACE1MEN1 | |
| SCHEMBL6872857 | 0.93 | ACHE (0.43) | ACHEAPPBCHEBACE1MCHR1 | |
| SCHEMBL6463524 | 0.93 | ACHE (0.43) | ACHEAPPBCHEBACE1MCHR1 | |
| SCHEMBL6875044 | 0.90 | ACHE (0.43) | ACHEAPPBCHEBACE1MEN1 | |
| SCHEMBL6873488 | 0.90 | ACHE (0.51) | ACHEAPPBCHEBACE1MCHR1 | |
| SCHEMBL6873495 | 0.90 | ACHE (0.51) | ACHEAPPBCHEBACE1MCHR1 | |
| SCHEMBL6875018 | 0.90 | ACHE (0.43) | ACHEAPPBCHEBACE1MEN1 | |
| SCHEMBL6877759 | 0.88 | MCHR1 (0.42) | ACHEAPPBCHEBACE1MCHR1 | |
| SCHEMBL6877765 | 0.88 | MCHR1 (0.42) | ACHEAPPBCHEBACE1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |