Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.43 |
| ▸ | PREP | P48147 | 3/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875277 | 1.00 | EPHX1 (0.56) | EPHX1KDM4ESIGMAR1PAK1GAA | |
| SCHEMBL6872862 | 0.88 | ALDH1A1 (0.56) | EPHX1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL6872864 | 0.88 | ALDH1A1 (0.56) | EPHX1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL6872853 | 0.88 | EPHX2 (0.47) | MEN1KMT2AMCHR1SMN1; SMN2MAPK8 | |
| SCHEMBL6872847 | 0.88 | EPHX2 (0.47) | MEN1KMT2AMCHR1SMN1; SMN2MAPK8 | |
| SCHEMBL6878450 | 0.87 | MAPK8 (0.41) | KDM4EALDH1A1MEN1KMT2AMCHR1 | |
| SCHEMBL6880649 | 0.87 | AURKB (0.41) | KDM4EALDH1A1MEN1KMT2AMCHR1 | |
| SCHEMBL6878449 | 0.87 | MAPK8 (0.41) | KDM4EALDH1A1MEN1KMT2AMCHR1 | |
| SCHEMBL6869279 | 0.87 | MAPK14 (0.54) | PAK1RAB9AMCHR1SMN1; SMN2MAPK8 | |
| SCHEMBL6869275 | 0.87 | MAPK14 (0.54) | PAK1RAB9AMCHR1SMN1; SMN2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |