Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687873 | 0.92 | PTGER3 (0.42) | MAPTITGB3ITGAVMMP12ITGB1 | |
| SCHEMBL686842 | 0.91 | PTGER3 (0.45) | MAPTITGB3ITGAVITGB1ITGA4 | |
| SCHEMBL688053 | 0.90 | PTGER3 (0.43) | MAPTPTGER3PPARGCNR2 | |
| SCHEMBL686896 | 0.89 | PTGER3 (0.44) | PTGER3CNR2 | |
| SCHEMBL688284 | 0.89 | PTGER3 (0.43) | MAPTITGB1ITGA4PTGER3CNR2 | |
| SCHEMBL29371834 | 0.89 | PTGER3 (0.44) | PTGER3CNR2 | |
| SCHEMBL687791 | 0.88 | PTGER3 (0.43) | PTGER3CNR2 | |
| SCHEMBL688581 | 0.88 | PTGER3 (0.44) | ITGB1ITGA4PTGER3CNR2FPR2 | |
| SCHEMBL687923 | 0.88 | PTGER3 (0.41) | ITGB1ITGA4PTGER3CNR2 | |
| SCHEMBL688983 | 0.87 | SMN1; SMN2 (0.42) | MAPTITGB1ITGA4PTGER3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |