Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 15/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 14/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875584 | 1.00 | EPHX1 (0.54) | EPHX1LMNAMCHR1ADRA2AHRH1 | |
| SCHEMBL6455682 | 0.91 | MCHR1 (0.44) | EPHX1LMNAMCHR1ADRA2AHRH1 | |
| SCHEMBL6455676 | 0.91 | MCHR1 (0.44) | EPHX1LMNAMCHR1ADRA2AHRH1 | |
| SCHEMBL6463572 | 0.91 | EPHX1 (0.42) | EPHX1LMNAMCHR1ADRA2AHRH1 | |
| SCHEMBL6463579 | 0.91 | EPHX1 (0.42) | EPHX1LMNAMCHR1ADRA2AHRH1 | |
| SCHEMBL6880504 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6880499 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877350 | 0.89 | ALPL (0.50) | EPHX1LMNAMCHR1ADRA2AHRH1 | |
| SCHEMBL6877569 | 0.89 | ALPL (0.50) | EPHX1LMNAMCHR1ADRA2AHRH1 | |
| SCHEMBL6877575 | 0.89 | ALPL (0.50) | EPHX1LMNAMCHR1ADRA2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |