Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NPR3 | P17342 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.36 |
| ▸ | HRH1 | P35367 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875589 | 1.00 | CYP2C9 (0.40) | CYP2C9NPR3CYP2C19PPIDSMN1; SMN2 | |
| SCHEMBL6875594 | 1.00 | CYP2C9 (0.40) | CYP2C9NPR3CYP2C19PPIDSMN1; SMN2 | |
| SCHEMBL6458993 | 0.90 | MCHR1 (0.40) | CYP2C9NPR3CYP2C19PPIDSMN1; SMN2 | |
| SCHEMBL6459003 | 0.90 | MCHR1 (0.40) | CYP2C9NPR3CYP2C19PPIDSMN1; SMN2 | |
| SCHEMBL6458998 | 0.90 | MCHR1 (0.40) | CYP2C9NPR3CYP2C19PPIDSMN1; SMN2 | |
| SCHEMBL6877392 | 0.86 | L3MBTL1 (0.41) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877397 | 0.86 | L3MBTL1 (0.41) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874610 | 0.84 | MAPK8 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874615 | 0.84 | MAPK8 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL5527235 | 0.81 | MCHR1 (0.55) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |