Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463374 | 1.00 | TRPV1 (0.38) | TRPV1KDM4EALDH1A1POLBAPP | |
| SCHEMBL6458932 | 0.94 | ALDH1A1 (0.41) | KDM4EALDH1A1POLBAPPBCHE | |
| SCHEMBL6458901 | 0.94 | ALDH1A1 (0.41) | KDM4EALDH1A1POLBAPPBCHE | |
| SCHEMBL6461007 | 0.91 | MCHR1 (0.38) | TRPV1APPBCHEACHEADRA2A | |
| SCHEMBL6460998 | 0.91 | MCHR1 (0.38) | TRPV1APPBCHEACHEADRA2A | |
| SCHEMBL6875692 | 0.87 | ALDH1A1 (0.52) | KDM4EALDH1A1POLBAPPBCHE | |
| SCHEMBL6875695 | 0.87 | ALDH1A1 (0.52) | KDM4EALDH1A1POLBAPPBCHE | |
| SCHEMBL6464454 | 0.84 | ALDH1A1 (0.37) | ALDH1A1ADRA2AMCHR1PARP1 | |
| SCHEMBL6464446 | 0.84 | ALDH1A1 (0.37) | ALDH1A1ADRA2AMCHR1PARP1 | |
| SCHEMBL6876919 | 0.84 | MCHR1 (0.41) | APPBCHEACHEADRA2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | claimed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | claimed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |