Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875695 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL6458932 | 0.91 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL6458901 | 0.91 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL6877060 | 0.89 | MCHR1 (0.41) | ALDH1A1KDM4EPOLBACHEBCHE | |
| SCHEMBL6877050 | 0.89 | MCHR1 (0.41) | ALDH1A1KDM4EPOLBACHEBCHE | |
| SCHEMBL6462936 | 0.88 | ALDH1A1 (0.51) | ALDH1A1KDM4EPOLBACHEBCHE | |
| SCHEMBL6873997 | 0.88 | ALDH1A1 (0.51) | ALDH1A1KDM4EPOLBACHEBCHE | |
| SCHEMBL6463374 | 0.87 | TRPV1 (0.38) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL6875645 | 0.87 | TRPV1 (0.38) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL6872433 | 0.86 | BCHE (0.43) | ALDH1A1KDM4EMEN1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |